Mixing Ibuprofen, Blood Pressure Meds May Damage Kidneys: Study

A study using computer-simulated drug trials found that people taking certain blood pressure medications along with painkillers such as ibuprofen may be risking kidney damage.

A research team at the University of Waterloo in Ontario, Canada, conducted computer-simulated drug trials to study the interactions of diuretics and RAS (renin-angiotensin system) inhibitors

which are often prescribed for people with high blood pressure, with ibuprofen, according to the study published in Mathematical Biosciences. Ibuprofen is sold over the counter as a pain reliever.

In some cases, the combination of the three drugs “significantly” increased the risk of acute kidney injury -- what the study called a “triple whammy.”

Using the three drugs was associated with a 31% increase in acute kidney damage compared to patients treated with two blood pressure drugs only, the study said.

“It’s not that everyone who happens to take this combination of drugs is going to have problems,” Anita Layton, PhD, professor of applied mathematics at Waterloo

The news release said computer-simulated drug trials can produce results faster than human clinical trials and “give medical practitioners a head start with issues like drug complications.”